Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw
Taiwan orthopedic insole OEM manufacturer
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.One-stop OEM/ODM solution provider Thailand
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China OEM factory for footwear and bedding
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia orthopedic insole OEM manufacturer
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Insole ODM factory in China
Alpha male of the Canyon pack in Yellowstone National Park. Credit: NPS/Neal Herbert A new study finds that the absence of gray wolves in western US ecosystems has significant ecological impacts, particularly on plant and animal communities. The study underscores the importance of historical context in ecological research and suggests that future studies should consider the presence of large predators for better conservation strategies. Importance of Gray Wolves in Ecosystems A study published today (June 19) in the journal BioScience sheds light on the importance of gray wolves in the western United States. Led by William Ripple, a scientist at Oregon State University and the Conservation Biology Institute, the research delves into the implications of large predator absence on plant and animal communities, and ecosystem functions. It calls attention to “shifting baselines” wherein increasingly degraded conditions are viewed as reflecting the historical state of a system. “By the 1930s, wolves were largely absent from the American West, including its national parks. Most published ecological research from this region occurred after the extirpation of wolves,” explains Ripple. “This situation underscores the potential impact of shifting baselines on our understanding of plant community succession, animal community dynamics, and ecosystem functions.” A wolf chases magpies and ravens from an elk carcass near Soda Butte, Yellowstone National Park. Credit: NPS/Jim Peaco Ecological Consequences of Predator Removal Age structure data for deciduous trees reveal substantial ecological impacts of elk and other ungulates following the removal of gray wolves from Yellowstone, Olympic, and Wind Cave National Parks. This has led to declines in long-term tree recruitment, influencing plant communities and ecological processes. The study highlights the necessity of characterizing historical context and reference conditions when exploring areas where large predators, like wolves, are either absent, functionally extinct, or persist in reduced densities. The authors note that such areas likely occur in many regions of the world as a result of the widespread loss of large predators. Where applicable, the authors recommend that researchers include a discussion of how the presence or absence of large predators may have influenced their results and conclusions in future ecological studies in national parks. Wolf in Lamar Valley, Yellowstone National Park. Credit: NPS/Jim Peaco Broader Implications and Recommendations “In addition to the loss or displacement of large predators, there may be other potential anthropogenic legacies within national parks that should be considered, including fire suppression, invasion by exotic plants and animals, and overgrazing by livestock,” adds Dr. Robert Beschta, co-author of the study and emeritus professor at Oregon State University. To address the effects of predator loss and other potential legacy factors, the study suggests that researchers investigate park archives to exploit historical data and information. National park archives can provide valuable insights into the history of predators and their prey, enabling scientists to discern among competing explanations for shifting ecological baselines. Wildlife Management and Conservation “Studying altered ecosystems without recognizing how or why the system has changed over time since the absence of a large predator could have serious implications for wildlife management, biodiversity conservation, and ecosystem restoration,” emphasizes Ripple. The research underscores the importance of integrating historical context into ecological studies to provide a more comprehensive understanding of ecosystem dynamics. By acknowledging the historical presence of large predators and other anthropogenic legacies, as well as their potential ecosystem effects, researchers can contribute to more effective conservation and management strategies in national parks and beyond. Legal and Conservation Efforts for Gray Wolves Recently, a coalition comprising nearly twelve conservation organizations initiated legal action against the U.S. Fish and Wildlife Service and the U.S. Department of the Interior. Their aim is to reinstate safeguards for gray wolves in Montana and Idaho, contending that the states’ forceful hunting strategies endanger these wolf populations. The research has implications for the long-term conservation of wolves and other large predators, including current gray wolf management and litigation in the West. “We hope our study will be of use to both conservation organizations and government agencies in identifying ecosystem management goals,” added Ripple. Reference: “A shifting ecological baseline after wolf extirpation” by William J Ripple, Christopher Wolf, Robert L Beschta, Apryle D Craig, Zachary S Curcija, Erick J Lundgren, Lauren C Satterfield, Samuel T Woodrich and Aaron J Wirsing, 19 June 2024, BioScience. DOI: 10.1093/biosci/biae034
The microprotein in the mitochondria (green) and in the nucleus (blue) was overexpressed in human cells. The yellow and pink areas show that the signal of the microprotein overlaps with the mitochondrial and nuclear signals. Credit: Clara Sandmann, Max Delbrück Center A new study has overturned the notion that microproteins, small proteins previously deemed unimportant, play no significant role in human cellular functions. The research, led by Professor Norbert Hübner and Dr. Sebastiaan van Heesch, has shown that these proteins, primarily found in humans, interact with larger, older proteins and play a key role in evolutionary development. The research also unveiled the smallest human proteins known, with potential implications for diseases like cardiovascular disease and cancer. Every biologist knows that small structures can sometimes have a big impact: Millions of signaling molecules, hormones, and other biomolecules are bustling around in our cells and tissues, playing a leading role in many of the key processes occurring in our bodies. Yet despite this knowledge, biologists and physicians long ignored a particular class of proteins – their assumption being that because the proteins were so small and only found in primates, they were insignificant and functionless. The discoveries made by Professor Norbert Hübner at the Max Delbrück Center and Dr. Sebastiaan van Heesch at the Princess Máxima Center for Pediatric Oncology in the Netherlands changed this view a few years ago: “We were the first to prove the existence of thousands of new microproteins in human organs,” says Hübner. In a paper that was recently published in the journal Molecular Cell, the team led by Hübner and van Heesch now describe how they systematically studied these miniproteins, and what they learned from them: “We were able to show which genome sequences the proteins are encoded in, and when DNA mutations occurred in their evolution,” explains Dr. Jorge Ruiz-Orera, an evolutionary biologist in Hübner’s lab and one of the paper’s three lead authors, who work at the Max Delbrück Center and the German Center for Cardiovascular Research (DZHK). Ruiz-Orera’s bioinformatic gene analyses revealed that most human microproteins developed millions of years later in the evolutionary process than the larger proteins currently known to scientists. Yet the huge age gap doesn’t appear to prevent the proteins from “talking” to each other. “Our lab experiments showed that the young and old proteins can bind to each other – and in doing so possibly influence each other,” says lead author Dr. Jana Schulz, a researcher in Hübner’s team and at the DZHK. She, therefore, suspects that, contrary to long-held assumptions, the microproteins play a key role in a variety of cellular functions. The young proteins might also be heavily involved in evolutionary development thanks to comparatively rapid “innovations and adaptations.” “It’s possible that evolution is more dynamic than previously thought,” says van Heesch. Proteins Only Found in Humans The researchers were surprised to find that the vastly younger microproteins could interact with the much older generation. This observation came from experiments performed using a biotechnical screening method developed at the Max Delbrück Center in 2017. In collaboration with Dr. Philipp Mertins and the Proteomics Platform, which the Max Delbrück Center operates jointly with the Berlin Institute of Health at Charité (BIH), the miniproteins were synthesized on a membrane and then incubated with a solution containing most of the proteins known to exist in a human cell. Sophisticated experimental and computer-aided analyses then allowed the researchers to identify individual binding pairs. “If a microprotein binds to another protein, it doesn’t necessarily mean that it will influence the workings of the other protein or the processes that the protein is involved in,” says Schulz. However, the ability to bind does suggest the proteins might influence each other’s functioning. Initial cellular experiments conducted at the Max Delbrück Center in collaboration with Professors Michael Gotthardt and Thomas Willnow confirm this assumption. This leads Ruiz-Orera to suspect that the microproteins “could influence cellular processes that are millions of years older than they are, because some old proteins were present in the very earliest life forms.” Unlike the known, old proteins that are encoded in our genome, most microproteins emerged more or less “out of nowhere – in other words, out of DNA regions that weren’t previously tasked with producing proteins,” says Ruiz-Orera. Microproteins, therefore, didn’t take the “conventional” and much easier route of being copied and derived from existing versions. And because these small proteins only emerged during human evolution, they are missing from the cells of most other animals, such as mice, fish and birds. These animals, however, have been found to possess their own collection of young, small proteins. The Smallest Proteins So Far During their work, the researchers also discovered the smallest human proteins identified to date: “We found over 200 super-small proteins, all of which are smaller than 16 amino acids,” says Dr. Clara Sandmann, the study’s third lead author. Amino acids are the sole building blocks of proteins. Sandmann says this raises the question of how small a protein can be – or rather, how big it must be to be able to function. Usually, proteins consist of several hundred amino acids. The small proteins that were already known to scientists are known as peptides and function as hormones or signal molecules. They are formed when they split off from larger precursor proteins. “Our work now shows that peptides of a similar size can develop in a different way,” says Sandmann. These smallest-of-the-small proteins can also bind very specifically to larger proteins – but it remains unclear whether they can become hormones or similar: “We don’t yet know what most of these microproteins do in our body,” says Sandmann. Yet the study does provide an inkling of what the molecules are capable of: “These initial findings open up numerous new research opportunities,” says van Heesch. Clearly, the microproteins are much too important for researchers to keep ignoring them. Van Heesch says the biomolecular and medical research communities are very enthusiastic about these new findings. One conceivable scenario would be “that these microproteins are involved in cardiovascular disease and cancer, and could therefore be used as new targets for diagnostics and therapies,” says Hübner. Several U.S. biotech companies are already doing research in this direction. And the team behind the current paper also has big plans: Their study investigated 281 microproteins, but the aim now is to expand the experiments to include many more of the 7,000 recently cataloged microproteins – in the hope that this will reveal many as-yet-undiscovered functions. Reference: “Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames” by Clara-L. Sandmann, Jana F. Schulz, Jorge Ruiz-Orera, Marieluise Kirchner, Matthias Ziehm, Eleonora Adami, Maike Marczenke, Annabel Christ, Nina Liebe, Johannes Greiner, Aaron Schoenenberger, Michael B. Muecke, Ning Liang, Robert L. Moritz, Zhi Sun, Eric W. Deutsch, Michael Gotthardt, Jonathan M. Mudge, John R. Prensner, Thomas E. Willnow, Philipp Mertins, Sebastiaan van Heesch and Norbert Hubner, 17 February 2023, Molecular Cell. DOI: 10.1016/j.molcel.2023.01.023
Amphiprion percula, a species of clownfish photographed in Kimbe Bay, Papua New Guinea. Credit: Tane Sinclair-Taylor The distinctive white stripes in clownfish form at different rates depending on their sea anemone hosts, a PNAS study finds. Clownfish species develop their characteristic white stripes, or bars, during the process of metamorphosis Researchers have now discovered that the white bars form at different speeds depending on the sea anemone the clownfish live in Thyroid hormones, which are important for metamorphosis, control the speed the white bars form Levels of thyroid hormones are higher in clownfish that live in the giant carpet anemone compared to clownfish living in the magnificent sea anemone Clownfish living in the giant carpet anemone also show increased activity of duox, a gene involved in forming thyroid hormones Charismatic clownfish, the coral reef fish made famous by the film Finding Nemo, are instantly recognizable by their white stripes. These stripes, which scientists call bars, appear as clownfish mature from larvae into adults in a process called metamorphosis, but how these distinctive patterns form has long remained a mystery. Now, a new study has found that the speed at which these white bars form depends on the species of sea anemone in which the clownfish live. The scientists also discovered that thyroid hormones, which play a key role in metamorphosis, drive how quickly their stripes appear, through changes in the activity of a gene called duox. “Metamorphosis is an important process for clownfish – it changes their appearance and also the environment they live in, as clownfish larvae leave life in the open ocean and settle in the reef,” said senior author Professor Vincent Laudet, who leads the Marine Eco-Evo-Devo Unit at the Okinawa Institute of Science and Technology Graduate University (OIST). “Understanding how metamorphosis changes depending on the sea anemone host can help us answer questions not only about how they adapt to these different environments, but also how they might be affected by other environmental pressures, like climate change.” In the study, published on May 24th, 2021 in PNAS, a team of researchers from the Centre for Island Research and Environmental Observatory (CRIOBE) in France first surveyed the clownfish species, Amphiprion percula, in Kimbe Bay, Papua New Guinea. The clownfish species, Amphiprion percula, relies on either the long-tentacled sea anemone, Heteractis magnifica (left) or the short-tentacled Stichodactyla gigantea (right) as its host. The sea anemones, armed with toxic stinging cells on their tentacles, protect clownfish from predators on the reef. The clownfish also protect the sea anemone from predators and provide nutrition and oxygenation to their host. Credit: Kina Hayashi The clownfish there can live either in the magnificent sea anemone, Heteractis magnifica, or the more toxic giant carpet anemone, Stichodactyla gigantea. During the survey, the team made a fascinating observation; the juvenile clownfish that lived in the giant carpet anemone gained their adult white bars faster than clownfish living in the magnificent sea anemone. During metamorphosis, the clownfish, Amphiprion percula, turns a vibrant orange and develops three white bars in succession, from head to tail. The rate at which the bars form depends on the sea anemone that the clownfish live in. Clownfish living in the long-tentacled anemone, Heteractis magnifica, (left) have fewer stripes than clownfish of the same age and size living in the shorter, carpet-style anemone, Stichodactyla gigantea (right). The image shows the typical appearance of clownfish aged 150-200 days. Credit: Fiona Lee, Academia Sinica, Taiwan “We were really interested in understanding not only why bar formation occurs faster or slower depending on the sea anemone, but also what drives these differences,” said first author Dr. Pauline Salis, a postdoctoral researcher at the Observatoire Océanologique de Banyuls-sur-Mer, Sorbonne Université Paris, who studies color patterning in coral reef fish. In the lab, the team worked with the clownfish, Amphiprion ocellaris, a close relative of Amphiprion percula. They focused on thyroid hormones, which are known to trigger metamorphosis in frogs. The clownfish, Amphiprion ocellaris, is one of the rare few species of coral reef fish that can be raised in a lab. Prof. Laudet uses the species to study the hormones involved in life history strategies, including metamorphosis. Credit: OIST The researchers treated larval clownfish with different doses of thyroid hormones. The higher the dose of thyroid hormones, the faster the clownfish developed the white bars, the team reported. Conversely, when the researchers treated the clownfish with a drug that stopped thyroid hormones from being produced, bar formation was delayed. The white bars form due to pigment cells, called iridophores, which express a specific subset of genes. Thyroid hormones accelerated white bar formation by activating these iridophore genes, the research team found. Clownfish larvae treated with thyroid hormones formed a higher number of bands at an earlier stage of development, compared to control larvae that weren’t treated with thyroid hormones. The image shows a control clownfish larvae (top) and a larvae five days after it was given a dose of thyroid hormones (bottom). Credit: Pauline Salis, first author Next, the scientists tested whether these observations held true the field. When the CRIOBE lab returned to Kimbe Bay, they transported juvenile clownfish from both species of sea anemone back to Dr. Salis in France. Levels of thyroid hormones were much higher in the clownfish from the giant carpet anemone than in the clownfish from the magnificent sea anemone, Dr. Salis confirmed. To gain insight into what caused these higher levels of thyroid hormones, the team measured the activity of most genes in the clownfish genome. “The big surprise was that out of all these genes, only 36 genes differed between the clownfish from the two sea anemone species,” said Prof. Laudet. “And one of these 36 genes, called duox, gave us a real eureka moment.” Duox, which makes the protein dual oxidase, plays an important role in the formation of thyroid hormones, previous research has shown. The duox gene showed higher levels of activity in clownfish from the giant carpet anemone, compared to clownfish from the magnificent sea anemone. Further experiments in collaboration with Professor David Parichy from the University of Virginia, U.S., confirmed that duox is important for developing iridophore pigment cells. When the duox gene is inactivated in mutant zebrafish, development of the iridophore pigment cells is delayed, the study found. Taken together, the data suggests that increased activity of duox in clownfish living in the giant carpet anemone result in higher levels of thyroid hormones, and thus the faster rate of white bar formation as iridophore pigment cells develop quicker. However, the research raises still more questions for the scientists to answer, including the ecological reason for this variation in the rate of white bar formation. It may be because the giant carpet anemone is more toxic, with thyroid hormone levels increasing as a response to stress, the researchers speculated. “Here at OIST, we’re starting to delve into some possible explanations,” said Prof. Laudet. “We suspect that these changes in white bar formation are just the tip of the iceberg, and that many other differences are present that help the clownfish adapt to the two different sea anemone hosts.” Reference: “Thyroid hormones regulate the formation and environmental plasticity of white bars in clownfishes” by Pauline Salis, Natacha Roux, Delai Huang, Anna Marcionetti, Pierick Mouginot, Mathieu Reynaud, Océane Salles, Nicolas Salamin, Benoit Pujol, David M. Parichy, Serge Planes and Vincent Laudet, 24 May 2021, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2101634118 Funding: Agence Nationale de la Recherche, National Institute of Science
DVDV1551RTWW78V
PU insole OEM production in China 》long-term production solutions with flexible volumeOne-stop OEM/ODM solution provider Taiwan 》seamless coordination from idea to finished productInnovative pillow ODM solution in China 》committed to helping you create value through custom manufacturing